We compared Rutin, Isoquercetin and Quercetin. See the results.

Rutin, Isoquercetin and Quercetin are bioflavonoids obtained from the Fava d’anta (Dimorphandra mollis Benth, a Brazilian native species) that is the main source for the industrial scale extraction of the Brazilian company Sanrisil.

Bioflavonoids are a class of natural compounds of considerable scientific and therapeutic interest. Its activity of combating free radicals is recognized and responsible for several health benefits.

Rutin

Rutin has a therapeutic importance due to its protective action of the small blood vessels, besides inhibiting the process of formation of free radicals in several stages contributing as antioxidant and anti-inflammatory. It has the appearance of greenish yellow fine powder.

 Quercetin

Quercetin is the most abundant flavonoid present in the human diet and accounts for about 95% of the total flavonoids ingested. Onions, apples and broccoli are the major sources of quercetin. It has been much studied in the last decades by the potential in the fight against free radicals, anticarcinogenic and its protective effects to the renal, cardiovascular and hepatic systems. It has the appearance of yellow-gold powder.

Isoquercetin

Isoquercetin has important therapeutic properties, such as the reduction of influenza virus replication, and is widely used in studies related to types of cancer with proliferative activity such as colon, lung and liver. In addition, isoquercetin has other important biological activities, such as antioxidant, anti-inflammatory and protective activity against atherosclerosis. The biological effects attributed to it are higher than the effects observed for quercetin and rutin, in this order (SALIM et al., 2004; FERNANDEZ et al., 2005).

 

QUERCETIN AND RUTIN COMPARATIVE STUDY OF THE SANSIRIL COMPANY

Purpose of the Study:

*Comparison of Routine (SR-DR 80 Rutin 80) and Quercetin (SR-DQ95 Quercetin 95) in the fight against free radicals – from Dimorphandra mollis (SANRISIL) in relation to Rutin (95%) and Quercetin (95%) from Sophora japonica;

*Realization of analyzes and data interpreted by invited researchers of the University of São Paulo (USP).

Results Found:

The test performed for the measurement of the free radicals present in the sample is observed in Graph 1.

The products (SR-DR80 Rutin 80 and SR-DQ95 Quercetin 95 from the Dimorphandra mollis plant – produced by Sanrisil) have superior results than the products from the Sophora japonica plant. Responsible for this is the high purity of these samples similar to the market standard. According to advanced studies conducted during 2014, both SR-DR80 Rutin 80 and SR-DQ95 Quercetin 95 were found to have a concentration greater than 85% and 95%, respectively.

SR-DR80 Rutin 80 has the power to inhibit the formation of free radicals of 8.3% stronger than Rutin to 95% of the other plant marketed by the other company. This shows its potent biological activity and superior quality as a product, shown in Chart 1. This product SR-DR80 Rutina 80 (concentration greater than 85%) has in its composition Isoquercetina around 8% and Quercetin 1% from the extraction process. This synergistic association causes the biological properties of inhibition of free radicals to be superior to routine samples without the presence of isoquercetin.

In other words, the biological activity demonstrated in this study is a quick and easy entry into the human body of these substances (rutin + isoquercetin), causing free radicals to be decreased and diseases such as cancer and aging being inhibited.

When the same comparison is made for the SR-DQ95 Quercetin 95 from Dimorphandra mollis – from the Sanrisil company, the quercetin from Sanrisil showed a biological activity 50% stronger than the quercetin from the other company from Sophora japonica.

CONCLUSIONS OF THIS STUDY:

The products of Sanrisil (SR-DR80 Rutina 80 and SR-DQ95 Quercetin 95 from the Dimorphandra mollis plant showed superior free radical fighting power results demonstrating a better interaction with the human organism and showing superior quality in its process extraction due to to the beneficial association with isoquercetin (concentration around 8%) in the sample of SR-DR80 Rutin 80, in addition to a higher degree of purity.

Chart 1. Fighting Free Radicals (Potential antiradical) expressed as the inhibitory concentration (IC50) in mg / mL

 REFERENCES

 

BRAND-WILLIANS, W.; CUVELICI, M. E.; BERSET, C. Use of a free radical method to evaluate antioxidant activity. Lebenswittel-Wissenschaft und Technologie, v. 28, p. 25-30, 1995.

 

FERNANDEZ, J.; REYES, R.; PONCE, H.; OROPEZA, M.; VAN CALSTEREN, M-R; JANKOWSKI, C.; CAMPOS, M.G. Isoquercitrin from Argemone platyceras inhibits carbachol and leukotriene D4-induced contraction in guinea-pig airways. European Journal of Pharmacology, 522, p. 108-115, 2005.

 

HALLIWELL, B. Free radicals and antioxidants: a personal view. Nutrition Reviews. v.52, n.8, p. 253-265, 1994.

 

OLTHOF, M. R.; HOLLMAN, P. C. H.; VREE, T. B.; KATAN, M. B. Bioavailabilities of quercetin-3-glucoside and quercetin-4′-glucoside do not differ in humans. Journal of Nutrition, v. 130, n. 5, p. 1200-1203, 2000.

 

PEDRIALI, C.A; FERNANDES, A. U.; SANTOS, P. A. DOS; SILVA, M. M.; SEVERINO, D.; SILVA, M. B. Antioxidant activity, cito- and phototoxicity of pomegranate (Punica granatum L.) seed pulp extract. Food Science and Technology (Campinas), v. 30, n. 4, p. 1017-1021, 2010. Disponível em: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-2061201000040002 8&lng =en&tlng=en.10.1590/ S010 1-20612010000400028. Acesso em: 23 jul 2014.

 

SALIM, E. I.; KANEKO, M.; WANIBUCHI, H.; MORIMURA, K.; FUKUSHIMA, S. Lack of

carcinogenicity of enzymatically modified isoquercitrin in F344/DuCrj rats. Food and Chemical Toxicology, v.42, n.12, p. 1949-1969, 2004.

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