Nature at the service of health

Sanrisil works with standardized active pharmaceutical ingredients that make up the base of the herbal medicine.

Active pharmaceutical ingredient (IFA): is an active chemical, drug or raw material with pharmacological properties for the purpose of medication used for the diagnosis, relief or treatment used to modify or exploit physiological systems or pathological conditions for the benefit of the person in which it is administered. It is the active principle of the medicine.

• Artichoke Dry Extract

Popular name: Artichoke
Used part: Leaves
Standardization/Marker: Caffeoylquinic acid derivatives expressed as chlorogenic acid
Vegetable derivative: Extract
Indications/Therapeutic actions: Cholagogue and choleretic. Treatment of symptoms of functional dyspepsia and mild to moderate hypercholesterolemia
Daily Dose 24 to 48 mg of caffeine derivatives expressed as chlorogenic acid
Administration Route: Oral
Restriction of use: Non-prescription sale

Source: NORMATIVE RESOLUTION No. 02 OF MAY 13, 2014.

• Monteverdia truncata Extract

Popular name: Espinheira-santa
Used part: Leaves
Standardization/Marker: Total tannins expressed as pyrogallol
Vegetal derivative: Extracts Allegation of use Dyspepsia, coadjuvant in the treatment of gastritis and gastroduodenal ulcer
Daily Dose: 60 to 90 mg total tannins expressed as pyrogallol
Administration Route: Oral
Restriction of use: Non-prescription sale

Source: INSTRUÇÃO NORMATIVA N° 02 DE 13 DE MAIO DE 2014

• Boldo Dry Extract

Popular name: Boldo
Used part: Leaves
Standardization/Marker: Total alkaloids expressed in boldine
Vegetal derivative: Extracts Allegation of use Cholagogue, choleretic, functional dyspepsia and spastic gastrointestinal disorders Daily Dose 2 to 5 mg total alkaloids expressed as boldine
Administration Route: Oral
Restriction of use: Non-prescription sale

Source: INSTRUÇÃO NORMATIVA N° 02 DE 13 DE MAIO DE 2014

• Cascara Extract

Popular name: Cascara
Used part: Bark
Standardization/Marker: Hydroxyanthracene derivatives expressed as cascaroside A Vegetable derivative Extracts
Indications/Therapeutic actions: Occasional constipation Daily Dose 20 to 30 mg of hydroxyanthracene derivatives expressed as cascaroside A
Administration Route: Oral
Restriction of use: Sale without prescription. Do not use continuously for more than a week.

Source: INSTRUÇÃO NORMATIVA N° 02 DE 13 DE MAIO DE 2014

• Passiflora Extract

Botanical nomenclature: Passiflora incarnata L.
Popular name: Passion fruit, Passiflora
Part Used: Air parts
Standardization/Marker: Total flavonoids expressed as vitexin
Vegetable Derivative: Extracts
Statement of use: Mild anxiolytic
Daily dose: 30 to 120 mg of total flavonoids expressed as vitexin
Administration route: Oral
Restriction of Use: Medicine without prescription

Source: NORMATIVE INSTRUCTION No. 10, DATED NOVEMBER 26, 2014

•  Crataegus Extract

Scientific name: Crataegus laevigata, Crataegus oxyacantha
Popular name: Cratego, hawthorn, white thorn, monogin, oxycanthus
Therapeutic use: Incorporated in pharmacopoeias around the world, including Brazil, with standardization of the amount of flavonoid glycosides in concentration greater than 0.5%. It has two main therapeutic activities: Cardiovascular and CNS.
Part Used: Flowers and Fruits
Usage and dosage forms: Intern use: 5% infusion for 15 minutes: 2 to 3 cups a day; Dye: 200 g of dried flowers in 1 liter of alcohol; Fluid extract (01 g = 50 drops): 0.5 to 2 g/day, divided into 2 to 3 shots/day; Dry Extract 5: 1: 0.6 to 1.5 g/day; Dye 1: 5 in 45% Alcohol: 1 to 2 ml 3X/day External Use: 5% infusion for sitz baths.
Contraindications: Pregnancy and Breastfeeding

Source: “Tratado de fitomedicina – bases clínicas e farmacológicas” (Phytomedicine Treaty – Clinical and Pharmacological Bases) Dr. Jorge R. Alonso – editor Isis. Buenos Aires – Argentina

• Salix Alba Extract

Botanical nomenclature: Salix alba
Popular nomenclature: White willow
Part(s) used: Stem bark
How to use: Decoction: 3 g in 150 mL (teacup)
Dosage and directions: Use 1 cup, 2 to 3x day
Route: Oral
Use: Adult
Statements: Inflammation, pain, and fever.
Contraindications: Do not use in people with gastrointestinal disorders and sensitivity to salicylic acid. Do not use on pregnant women and children.

Source: Publication of the Regional Council of Pharmacy of the State of Sao Paulo – April/2019 – ADVISORY COMMITTEE ON MEDICAL PLANTS AND HERBAL MEDICINES

•  Horse Chestnut Extract

Botanical nomenclature:  Aesculus hippocastanum
Popular nomenclature: Horse Chestnut
Part(s) used: Seeds with bark
How to use: Decoction: 1.5 g in 150 mL (cup of tea)
Dosage and directions: Use 1 teacup Twice a day, right after meals.
Route: Oral
Use: Adult
Statements: Capillary fragility, venous insufficiency (hemorrhoids and varicose veins)
Contraindications: Do not use in pregnancy, lactation, hepatic and renal failure, as well as in cases of active digestive mucosal lesions.
Side Effects: High doses may cause digestive tract irritation, nausea, and vomiting.
Additional Information on Packaging: Do not use in conjunction with anticoagulants

Source: Publication of the Regional Council of Pharmacy of the State of Sao Paulo – April/2019 – ADVISORY COMMITTEE ON MEDICAL PLANTS AND HERBAL MEDICINES

•  Ginkgo Biloba Extract

Botanical nomenclature: Ginkgo biloba
Popular name: Ginkgo
Part Used: Leaves
Standardization/Marker: Ginkgo flavonoids (22% to 27%) expressed as quercetin, kaempferol, and isorhamnetin; and terpenolactones (5% to 7%) expressed as ginkgolides A, B, C and bilobalide Negative marker: Ginkgolic acids less than 5 µg/g.
Vegetable Derivative: Extracts
Indications/Therapeutic Actions: Vertigo and tinnitus resulting from circulatory disorders, peripheral circulatory disorders (intermittent claudication) and cerebrovascular insufficiency Daily dose 26.4 to 64.8 mg ginkgo flavonoids, and 6 to 16.8 mg terpenolactones.
Administration route: Oral
Restriction of Use: Prescription-only medicines

Source: NORMATIVE RESOLUTION No. 02, MAY 13, 2014.

 •  Chamomile Extract

Botanical nomenclature: Matricaria recutita
Popular nomenclature: Chamomile
Part(s) used: Floral Chapters
How to use: Infusion: 3 in 150 mL (teacup or infusion: 6-9 g in 150 mL (teacup)
Dosage and directions: Use 1 teacup 3-4x daily or Apply 3-4x daily in the form of compresses, mouthwash and gargling.
Route: Oral or Topic
Use: Adult/Child
Statements: Intestinal cramps. Mild anxiety symptoms, mild soothing or bruising and inflammatory processes of the mouth and gums.
Contraindications: Do not use during pregnancy.
Side Effects: In case of overdose, nausea, nervous excitement, and insomnia may occur. Avoid use in persons allergic or hypersensitive to plants of the Asteraceae family.
Additional Information on Packaging: Do not use the infuse near the eyes.

Source: Publication of the Regional Council of Pharmacy of the State of Sao Paulo – April/2019 – ADVISORY COMMITTEE ON MEDICAL PLANTS AND HERBAL MEDICINES

 •  Valerian Extract

Botanical nomenclature: Valeriana officinalis
Popular name: Valerian
Part Used: Roots
Standardization/Marker: Sesquiterpenic acids expressed as valerenic acid
Vegetable Derivative: Extracts
Indications/Therapeutic Actions: Moderate sedative, hypnotic, and in the treatment of anxiety-related sleep disorders
Daily dose: 1 to 7.5 mg of sesquiterpenic acids expressed as valerenic acid
Administration route: Oral
Restriction of Use: Prescription-only medicines

Source: NORMATIVE RESOLUTION No. 02, MAY 13, 2014.

  •  Hyperic Extract

Botanical nomenclature: Hypericum perforatum L.
Popular name: Hyperic
Part Used: Air parts
Standardization/Marker: Total hypericins expressed as hypericin
Vegetable Derivative: Extracts
Indications/Therapeutic Actions: Mild to moderate depressive states Daily Dose 0.9 to 2.7 mg total hypericin expressed hypericins
Administration route: Oral
Restricted Use Sale: Prescription-only

Source: NORMATIVE RESOLUTION No. 02, MAY 13, 2014.

• Yerba Mate Extract

Scientific name: Ilex paraguariensis.
Scientific synonymy: Ilex curitibensis Miers, Ilex domestic Reiss, Ilex mate A. St. Hil, Ilex sorbilis Reiss, Ilex vestila Reiss.
Popular name: Mate, yerba mate, erveira, congonha, erva, erva-verdadeira, ervacongonha (in Brazil)
Part(s) used: Leaves
Dosage and directions: Dry Extract: 100 to 300 mg before main meals.
Indications: Fatigue, overweight (supplement in case of diet), cellulite, diabetes, reduction of bad cholesterol (LDL).  Osteoporosis and prevention in postmenopausal women.
Secondary effects: Excitement, nervousness.
Contraindications: Heart problems (due to its caffeine content).

Source: Frontiers in Physiology (DOI: 10.3389/fphys.2018.00315), The Lancet

• Green tea

Popular name: Green tea, Black tea, Tea.
Scientific name: Cammelia sinensis (L.) Kutntze
Properties: stimulant, anti-itching (reduction of itching), anti-inflammatory, anti-allergic, anticancer, anti-ulcer.
Part Used: New leaves.
Use: It is mainly used as a stimulating drink, similar to coffee, guarana, and mate. Black tea compresses have been recommended for treating skin problems, relieving inflammation and itching.
Other actions reported are the inhibition of growth of the main cause of dental caries (Streptococcus mutans), anti-allergic, anticancer, anti-ulcer activity, in addition to lowering blood cholesterol. There is also preventive and curative action in diarrhea caused by rotavirus, cholera, and food toxins.
Recommended Use/Dosage: Its use is recommended in the form of teas prepared by infusion.

Source: Lorenzi, H. et al. 2002. Medicinal Plants in Brazil. /Vieira, L. S. 1992. Amazonian herbal medicine.